Globally sclerotic glomeruli in IgA nephropathy patients
نویسنده
چکیده
C om m en ta ry Implication for health policy/practice/research/medical education: Oxford classification system was based on actual clinical data, international collaboration, and validation of the reproducibility of defining pathologic lesions. The strongest pathologic predictor of clinical outcome in IgA nephropathy is the extent of tubular atrophy and interstitial fibrosis. A R T I C L E I N F O
منابع مشابه
Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients
INTRODUCTION Immunoglobulin A nephropathy is the most common form of glomerular nephropathy among children and young adults. OBJECTIVES To evaluate the possible correlation between the extent of sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy (IgAN) patients, we conducted an observational study, on 136 IgAN patients' biopsies. PATIENTS AND METHODS ...
متن کاملComment on: Association between the proportion of globally sclerotic glomeruli and various morphologic variables and clinical data of IgA nephropathy patients
Implication for health policy/practice/research/medical education: It is essential to conduct more studies using a larger number of patients or studies from different geographic parts and ethnicities to obtain the other important prognostic morphologic variables, other than four morphologic variables of Oxford classification. Commentary Please cite this paper as: Baradaran A. Comment on: Associ...
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BACKGROUND Global glomerulosclerosis is characteristic of chronic kidney disease and also occurs with normal aging. Our goal was to determine the upper limit of normal for number of globally sclerotic glomeruli. METHODS Core-needle biopsies of the renal cortex were obtained at the time of living kidney transplantation at three centers between 1998 and 2011. The number of globally sclerotic gl...
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Mesangial matrix expansion is a prominent feature of the most common form of glomerulonephritis, IgA nephropathy (IgAN). To find molecular markers and improve the understanding of the disease, the gene and protein expression of proteoglycans were investigated in biopsies from IgAN patients and correlated to clinical and morphological data. We collected and microdissected renal biopsies from IgA...
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